Dra. María Teresa Roldán. (Univ. Córdoba)
Jueves, 6 de junio de 2019. 12:00 h
Salón de Grados cicCartuja2
Base excision repair (BER) is a crucial defense pathway that replaces damaged DNA bases. It is a multistep process initiated by DNA glycosylases, small enzymes that excise the altered base and generate an intermediate that must be processed by additional proteins before repair is completed. BER has been extensively studied in bacteria, yeast, and mammals.
Results obtained so far in plants indicate that they share many BER components with other organisms, but possess some distinctive features. Among other BER innovations, plants have evolved an unique family of large DNA glycosylases that excise 5-methylcytosine (5-meC), allowing its replacement with unmethylated C. These enzymes, typified by Arabidopsis ROS1 and DME, initiate a BER-based, active DNA demethylation pathway that prevents hypermethylation and plays important functions in genome imprinting and seed development. After 5-meC excision, ROS1/DME proteins incise the sugar-phosphate backbone, generating single nucleotide gaps with non-canonical 3´-ends that are processed by additional BER enzymes, such as APE1L and ZDP. Another repair-related factor, DDB2, avoids accumulation of potentially harmful DNA demethylation intermediates and coordinates methylation and demethylation activities.
Thus, beyond its canonical role in genome maintenance, the plant DNA repair machinery performs critical functions in epigenetic regulation.
El Consistorio reconoce su investigación en el diseño y fabricación de dispositivos optoelectrónicos basados en perovskitas.
El acto público de entrega del “Premio cicCartuja Ebro Foods” tendrá lugar el viernes 28 de abril de 2017
Sus estudios se centran en procesos catalíticos para síntesis orgánica y aplicaciones en química verde o sostenible
El taller se celebra el 2 de marzo y está orientado a las convocatorias Advanced 2017 y futuras convocatorias de 2018
Esta iniciativa, promovida por estudiantes de Doctorado del centro, establecerá lazos de colaboración entre investigadores y enriquecerá su formación.
Científicos del ICMS fabrican un material a base de silicio y helio que resulta estable durante años e inalterable a altas temperaturas
Este evento nacional potenciará el contacto entre empresas, centros tecnológicos y el mundo académico