Prof. Amir Hoveyda. Department of Chemistry, Boston College (USA) & Institute de Science et d’Ingénierie Supramoléculaires, University of Strasbourg (France)
Martes, 18 de febrero de 2020. 12:00 h
Salón de Grados de cicCartuja
Efficient synthesis of enantiomerically enriched amines often demands oxidation-state adjustments, protection/deprotection processes, and purification procedures that increase cost and waste, and limit applicability. When diastereomers can be formed, one isomer is attainable. In this Lecture we will discuss how nitriles, commonly viewed as insufficiently reactive, can be transformed directly to multifunctional unprotected homoallylic amines by enantioselective addition of a carbon-based nucleophile and diastereodivergent reduction of the resulting ketimine. Successful implementation requires that competing copper-based catalysts be present simultaneously, and that the slower-forming and less-reactive one engages first. This challenge was addressed by incorporation of a nonproductive side-cycle, fueled selectively by inexpensive additives, to delay the function of the more active catalyst.
Estudiantes de toda Europa explorarán cómo la innovación comparte procesos comunes en el arte y en la ciencia.
Dos investigadores del cicCartuja galardonados: Isabel Cruz-Gallardo, IBVF, y Juan C. Muñoz-García, IIQ.
Por primera vez se desarrolla un método sencillo y de bajo coste que une el compuesto metálico con esta especia
La Sociedad Española de Catálisis reconoce como mejor del 2014 a su trabajo doctoral realizado en el ICMS
El cicCartuja colabora en su organización para estrechar lazos entre el sector privado y los organismos públicos de investigación
The Academy acknowledges his studies of functional nanomaterials with applications in photonics, electronics and sensors