Dra. María Teresa Roldán. (Univ. Córdoba)
Jueves, 6 de junio de 2019. 12:00 h
Salón de Grados cicCartuja2
Base excision repair (BER) is a crucial defense pathway that replaces damaged DNA bases. It is a multistep process initiated by DNA glycosylases, small enzymes that excise the altered base and generate an intermediate that must be processed by additional proteins before repair is completed. BER has been extensively studied in bacteria, yeast, and mammals.
Results obtained so far in plants indicate that they share many BER components with other organisms, but possess some distinctive features. Among other BER innovations, plants have evolved an unique family of large DNA glycosylases that excise 5-methylcytosine (5-meC), allowing its replacement with unmethylated C. These enzymes, typified by Arabidopsis ROS1 and DME, initiate a BER-based, active DNA demethylation pathway that prevents hypermethylation and plays important functions in genome imprinting and seed development. After 5-meC excision, ROS1/DME proteins incise the sugar-phosphate backbone, generating single nucleotide gaps with non-canonical 3´-ends that are processed by additional BER enzymes, such as APE1L and ZDP. Another repair-related factor, DDB2, avoids accumulation of potentially harmful DNA demethylation intermediates and coordinates methylation and demethylation activities.
Thus, beyond its canonical role in genome maintenance, the plant DNA repair machinery performs critical functions in epigenetic regulation.
Los estudiantes han pasado la mañana en los laboratorios acompañados por científicos del centro
El próximo 27 de junio se celebrará en el cicCartuja un acto con motivo de esta efeméride
Numerosos investigadores del Instituto de Ciencia de Materiales entre los miembros de los distintos comités
La formación, de carácter intensivo, tendrá lugar del 20 al 24 de junio
La joven investigadora recibe la distinción por sus estudios sobre la caracterización de materiales catalíticos nanoestructurados
Su proyecto consigue el Premio a la Excelencia a la Investigación en Innovación
El Catedrático del Instituto de Investigaciones Químicas ofrece su visión sobre la situación de la ciencia en España