Titulo: Bacterial flagellum assembly and coupled gene regulatory mechanisms
Conferenciante: Prof. Kelly T. Hughes (Department of Biology, University of Utah Salt Lake City, USA)
Fecha: viernes, 15 de septiembre de 2017
Horario: 12:00 h
Lugar: Salón de Grados cicCartuja2
Abstract: Many bacteria swim using propeller devices called flagella that rotate at rates up to 60,000 rpm. The bacterial flagellum is a complex organelle with many parts that must be assembled in a sequential order. The flagellar and chemosensory network includes more than 60 genes. For many pathogens such as Salmonella, flagella play a crucial role in bacterial virulence. They are required to reach sites of infection and to initiate biofilm formation. Most of the flagellum is assembled outside the cytoplasm and beyond the surface of the cell. This has required the development of mechanisms of self-assembly and nano-scale length control to overcome the formidable problem of building this structure. We have shown that the 22-nm flagellar driveshaft is determined by the length of Braun's lipoprotein, which tethers the outer membrane to the cell wall. We have shown that flagellar gene regulation is coupled to assembly at the completion of the flagellar motor: the hook-basal body (HBB). A secreted molecular ruler measures a minimal length for the extracellular hook and then signals the flagellar type III secretion system to change secretion specificity from proteins needed for HBB assembly to filament substrates. Transcriptional anti-regulators are also secreted to time the cessation of HBB gene expression and the initiation of filament and chemosensory genes to completion of the HBB.
Miembros del IIQ organizan esta actividad de divulgación gratuita, orientada a la comunidad universitaria que tendrá lugar el viernes 24 de marzo a partir de las 12:30h.
Este premio reconoce la trayectoria del investigador del ICMS, en supervisión y formación de jóvenes investigadores y la dirección de tesis doctorales.
El grupo del Dr. Jesús Angulo, lidera el área de glicovirología estructural, del proyecto europeo GlycoNoVi.
It will be held in Seville (Spain), on 10 - 11 March 2020, under the auspices of Ramón Areces Foundation at cicCartuja.
El investigador, que realizó su Tesis en el IBVF, ha sido premiado con este galardón que reconoce su trabajo en el Grupo RNAS Reguladores de Cianobacterias
Ha sido reconocido como investigador altamente citado en la lista HCR 2022, donde se reunen los científicos más influyentes a nivel mundial.