Dra. María Teresa Roldán. (Univ. Córdoba)
Jueves, 6 de junio de 2019. 12:00 h
Salón de Grados cicCartuja2
Base excision repair (BER) is a crucial defense pathway that replaces damaged DNA bases. It is a multistep process initiated by DNA glycosylases, small enzymes that excise the altered base and generate an intermediate that must be processed by additional proteins before repair is completed. BER has been extensively studied in bacteria, yeast, and mammals.
Results obtained so far in plants indicate that they share many BER components with other organisms, but possess some distinctive features. Among other BER innovations, plants have evolved an unique family of large DNA glycosylases that excise 5-methylcytosine (5-meC), allowing its replacement with unmethylated C. These enzymes, typified by Arabidopsis ROS1 and DME, initiate a BER-based, active DNA demethylation pathway that prevents hypermethylation and plays important functions in genome imprinting and seed development. After 5-meC excision, ROS1/DME proteins incise the sugar-phosphate backbone, generating single nucleotide gaps with non-canonical 3´-ends that are processed by additional BER enzymes, such as APE1L and ZDP. Another repair-related factor, DDB2, avoids accumulation of potentially harmful DNA demethylation intermediates and coordinates methylation and demethylation activities.
Thus, beyond its canonical role in genome maintenance, the plant DNA repair machinery performs critical functions in epigenetic regulation.
Jornadas donde los participantes tienen acceso a proyectos ganadores del ERC
El investigador del IIQ, ha obtenido uno de los Premios Jóvenes Investigadores que otorga esta corporación
Los relatos ganadores en las categorías A y B pasarán a concursar en la Fase Internacional.
El investigador del IBVF, Federico Valverde es uno de los ponentes que rinde homenaje a su padre en esta mesa redonda sobre "Ciencia y Conservación en Doñana"
El ganador del Premio ha sido el stand del IES Gran Capitán e IES Martín Rivero.
Vuelve el Concurso de Nanorelatos: "Caben muchas historias en el nanomundo: ¡cuéntanoslas!" dentro del VIII Festival de Nanociencia y Nanotecnología 10alamenos9
El Primer Premio a Javier Castillo del ICMS, Primer Accésit para Pedro de los Reyes del IBVF y Segundo Accésit ex aequo para Marina Pérez y Helena Corona, ambas del IIQ