Dra. María Teresa Roldán. (Univ. Córdoba)
Jueves, 6 de junio de 2019. 12:00 h
Salón de Grados cicCartuja2
Base excision repair (BER) is a crucial defense pathway that replaces damaged DNA bases. It is a multistep process initiated by DNA glycosylases, small enzymes that excise the altered base and generate an intermediate that must be processed by additional proteins before repair is completed. BER has been extensively studied in bacteria, yeast, and mammals.
Results obtained so far in plants indicate that they share many BER components with other organisms, but possess some distinctive features. Among other BER innovations, plants have evolved an unique family of large DNA glycosylases that excise 5-methylcytosine (5-meC), allowing its replacement with unmethylated C. These enzymes, typified by Arabidopsis ROS1 and DME, initiate a BER-based, active DNA demethylation pathway that prevents hypermethylation and plays important functions in genome imprinting and seed development. After 5-meC excision, ROS1/DME proteins incise the sugar-phosphate backbone, generating single nucleotide gaps with non-canonical 3´-ends that are processed by additional BER enzymes, such as APE1L and ZDP. Another repair-related factor, DDB2, avoids accumulation of potentially harmful DNA demethylation intermediates and coordinates methylation and demethylation activities.
Thus, beyond its canonical role in genome maintenance, the plant DNA repair machinery performs critical functions in epigenetic regulation.
El investigador participó en esta actividad con una charla sobre nanomateriales ópticos y su integración en dispositivos lumínicos
La singularidad de sus equipos, en concreto del espectrómetro de RMN de alto campo, ha permitido su inclusión en la Red
Varias de sus patentes mejoran la eficiencia de luminarias y están siendo explotadas por una gran multinacional
Por su capacidad para aunar la ciencia básica de gran calidad e impacto con la transferencia tecnológica de alto nivel.
Será responsable de un nuevo grupo que desarrollará catalizadores diferentes a los empleados actualmente en la industria
Participarán investigadores de Cabimer o la Estación Biológica de Doñana, entre otros centros del CSIC.
Calvo revisa el campo de las perovskitas ABX3 en el especial del Journal of Materials Chemistry A de la Royal Society of Chemistry