cicCartuja Centro de Investigaciones Científicas de la cartuja
Título: Novel Photo- and Organo-catalytic Reactions for the Construction of C-C Bonds
Conferenciante: Dr. José Alemán Lara (Universidad Autónoma de Madrid)
Fecha: viernes, 15 de febrero de 2019
Horario: 12:30 h
Lugar: Salón de Actos cicCartuja
Abstact
Photo-induced transformations have been at the forefront of chemical research for many years, yet lately they have received enormous interest. The basis for modern photocatalytic methodologies is set on the transmission of photons to a specific molecule - a photosensitizer, which can be parlayed into the population of the molecule’s excited state. This energy can then be transferred to other substrates via energy or electron transfer, wherein the pairing of excited-state energies and of redox potentials, respectively, of the sensitizer and the reactive substrate is crucial for a successful outcome in photochemical reactions. Very recently, our group has started a new research line concerning the use of photochemistry for different reactions, such as thiol-ene/oxidation tandem reactions,[1] asymmetric alkylation of aldehydes2 and ring opening cyclopropane expansions.3 More recently, we have found that the rupture of C-O bonds is possible and can be used for further transformations.
In the second part of this talk, I will present an approach for the asymmetric synthesis of tricyclic compounds, via desymmetrization of cyclohexadienones under aminocatalytic conditions.4 At the end of this communication, the use of bifunctional catalytic systems for the activation of silyl-dienol ethers for the synthesis of Rauhut-Currier type products will be presented.5. Finally, the use of different organocatalytic intramolecular activation with hydroxyl groups for the synthesis of pyrrolidines and aminoacids will be also shown.6
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[1]. Guerrero-Corella, A.; Martinez, A. M.; Ahmadi, F.; Ming, E.; Fraile, A.; Alemán, J. Chem. Commun, 2017, 53, 10463.
2. Rigotti, T.; Casado-Sánchez, A.; Cabrera, S.; Pérez-Ruiz, R.; Liras, M.; A. de la Peña O'Shea, V.; Alemán, J. ACS-Catalysis, 2018, 8, 5928
3. Luis-Barrera, J.; Laina-Martín, V.; Rigotti, T.; Peccati, F.; Solans-Monfort, X.; Sodupe, M.; Mas-Ballesté, R.; Liras, M.; Alemán, J. Angew. Chem. Int. Ed. 2017, 56, 7826.
4. Martín-Santos, C.; Jarava-Barrera, C.; del Pozo, S.; Parra, A.; Díaz-Tendero, S.; Mas-Ballesté, R.; Cabrera, S.; Alemán, J. Angew. Chem. Int. Ed. 2014, 53, 8184.
5. Frias, M.; Mas-Ballesté, R.; Arias, S.; Alvarado, C.; Alemán, J. J. Am. Chem. Soc. 2017, 139, 672.
6. a) Esteban, F.; Cieślik, W.; Arpa, E. M.; Guerrero, A.; Díaz Tendero, S.; Perles, J.; Fernández-Salas, J. A.; Fraile, A.; Alemán, J. ACS-Catalysis, 2018, 8, 1884; b) Guerrero-Corella, A.; Esteban, F.; Iniesta, M.; Martín-Somer, A.; Parra, M.; Díaz-Tendero, S.; Fraile, A.; Alemán, J. Angew. Chem. Int. Ed. 2018,
Miembros del IIQ organizan esta actividad de divulgación gratuita, orientada a la comunidad universitaria que tendrá lugar el viernes 24 de marzo a partir de las 12:30h.
Este premio reconoce la trayectoria del investigador del ICMS, en supervisión y formación de jóvenes investigadores y la dirección de tesis doctorales.
El grupo del Dr. Jesús Angulo, lidera el área de glicovirología estructural, del proyecto europeo GlycoNoVi.
It will be held in Seville (Spain), on 10 - 11 March 2020, under the auspices of Ramón Areces Foundation at cicCartuja.
El investigador, que realizó su Tesis en el IBVF, ha sido premiado con este galardón que reconoce su trabajo en el Grupo RNAS Reguladores de Cianobacterias
Ha sido reconocido como investigador altamente citado en la lista HCR 2022, donde se reunen los científicos más influyentes a nivel mundial.
