Dra. María Teresa Roldán. (Univ. Córdoba)
Jueves, 6 de junio de 2019. 12:00 h
Salón de Grados cicCartuja2
Base excision repair (BER) is a crucial defense pathway that replaces damaged DNA bases. It is a multistep process initiated by DNA glycosylases, small enzymes that excise the altered base and generate an intermediate that must be processed by additional proteins before repair is completed. BER has been extensively studied in bacteria, yeast, and mammals.
Results obtained so far in plants indicate that they share many BER components with other organisms, but possess some distinctive features. Among other BER innovations, plants have evolved an unique family of large DNA glycosylases that excise 5-methylcytosine (5-meC), allowing its replacement with unmethylated C. These enzymes, typified by Arabidopsis ROS1 and DME, initiate a BER-based, active DNA demethylation pathway that prevents hypermethylation and plays important functions in genome imprinting and seed development. After 5-meC excision, ROS1/DME proteins incise the sugar-phosphate backbone, generating single nucleotide gaps with non-canonical 3´-ends that are processed by additional BER enzymes, such as APE1L and ZDP. Another repair-related factor, DDB2, avoids accumulation of potentially harmful DNA demethylation intermediates and coordinates methylation and demethylation activities.
Thus, beyond its canonical role in genome maintenance, the plant DNA repair machinery performs critical functions in epigenetic regulation.
Miguel hizo su tesis en el MOM, el grupo de investigación del ICMS
Jesús es nombrado vicepresidente del Grupo Especializado de Resonancia Magnética Nuclear de la Real Sociedad Española de Química.
Los premiados en el concurso de 10alamenos9 en Andalucía, ya han recibido su reconocimiento y diploma acreditativo.
El investigador del ICMSE es editor jefe de esta prestigiosa revista, en la sección Nanomateriales
El investigador recibirá esta condecoración que reconoce la excelencia en la calidad científica y en la trayectoria profesional de jóvenes promesas españolas menores de 40 años.
Seleccionado en el XX Concurso Nacional para la adjudicación de Ayudas a la Investigación en ciencias de la Vida y de la Materia
Cristina, que hizo su doctorado en el ICMS, afrontará con su investigación el reciclaje de plásticos y residuos de biomasa para la generación de biopolímertos