cicCartuja Centro de Investigaciones Científicas de la cartuja

Ir-Catalyzed Asymmetric Hydroarylation of Alkynes for the Synthesis of Axially Chiral Heterobiaryls

IIQ

Pablo Vázquez Domínguez, Antonio Romero Arenas, Rosario Fernández, José María Lassaletta, Abel Ros ACS Catalysis 2023, Vol. 13, 42-28

The catalytic hydroarylation of alkynes has emerged as an excellent methodology for the synthesis of functionalized alkenes with excellent levels of regio- and stereocontrol (syn). However, in spite of the great progress in this field, the number of asymmetric methodologies is still scarce. Herein, we report an atroposelective Ir-catalyzed C–H hydroarylation of alkynes, which enables the asymmetric synthesis of axially chiral heterobiaryl trisubstituted olefins in good to high yields and enantioselectivities up to 98% ee.

https://doi.org/10.1021/acscatal.2c04524

 

El investigador Pablo Vázquez Domínguez